By Graca Soveral,Soren Nielsen,Angela Casini

Since the invention of Aquaporin-1 (AQP1) as a water channel, many reviews have published the significance of aquaporins in mammalian body structure and pathophysiology in addition to plant and microbial biology. The reports have additionally proven aquaporins as capability drug objectives and ambitions for bettering crop properties.

Written by means of a world staff of individuals on the leading edge of the sector, Aquaporins in well-being and affliction: New Molecular pursuits for Drug Discovery offers the newest examine advances in aquaporins and different significant intrinsic protein (MIP) channels. the 1st portion of the ebook describes the final ideas of aquaporin channel functionality, genomic learn, structure-function research of aquaporins and glycerol facilitators, and rules via gating and trafficking, together with yeast aquaporin rules and serve as. the second one part discusses the physiological and pathophysiological roles of aquaporins in people and microbes. the ultimate part covers the improvement of inhibitors of aquaporin functionality. The book’s epilogue deals destiny views and instructions, often within the quarter of aquaporin-based diagnostics and therapeutics.

Stimulating destiny examine in this vital protein kinfolk, this e-book allows a paradigm shift within the figuring out and roles of aquaporin membrane proteins in all organic settings. It encourages scientists to advance novel ways for the therapy of human illnesses according to aquaporin functionality or dysfunction.

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Aquaporins in Health and Disease: New Molecular Targets for Drug Discovery by Graca Soveral,Soren Nielsen,Angela Casini

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